Bill O'Brien is a television series actor, and the Senior Advisor for Program Innovation for the National Endowment of the Arts.

Bill O'Brien was appointed to serve as Deputy Chairman of Grants and Awards for the National Endowment for the Arts shortly after the election of President Barack Obama in 2008 where he supervised the design and implementation of grants and awards programs, designed and led national leadership initiatives, developed partnerships to advance discipline fields, and managed the panel review process across multiple arts disciplines.